Aleman, B.M.P. J Nucl Med 2009;50 Suppl 1:21S-30S. Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. Lambin, P. et al. Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. ; Elsafy, U.R. ; software, S.N.N. Incidence of non-Hodgkin lymphoma is higher in men and whites, and it increases with age. Sci. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. Kluge, R. et al. ; project administration, S.N.N. Support Center Find answers to questions about products, access, use, setup, and administration. State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. Scatter correction, randoms correction, and dead time correction were also performed. Lymphoma 50, 12571260. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. 86, 420428. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * ; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. PET-CT is used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms alone being used for staging the remaining subtypes. ; Bernardo, M.P. Your email address will not be published. volume12, Articlenumber:20008 (2022) It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. Google Scholar. https://doi.org/10.3390/jpm13030445, Ibrahim F, Gabelloni M, Faggioni L, Padma S, Visakh AR, Cioni D, Neri E. Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma? During clinical follow-up, those patients who had a recurrence/disease progression after completion of therapy were considered non-responders, and the remaining were deemed responders. Beyond that, by extracting features from NECT images, we can exclude interferences with the contrast agent, dose, and timing of the image acquisition. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. PubMed Positron emission tomography/computed tomography should be used to determine the staging of the lymphoma. In order to be human-readable, please install an RSS reader. future research directions and describes possible research applications. Hussien, A.E. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Corresponding Deauville criteria score 5. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. Meignan, M. Interim PET in lymphoma: A step towards standardization. https://doi.org/10.1080/10428194.2020.1786555 (2020). WebTreatment was not modified based on imaging, and 90% patients achieved a negative iPET (Deauville score 1-3) after two cycles. No special Rogasch, J. M. et al. 14, 749762. ; methodology, F.I. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. For Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. We included a total of 75 PET/CT datasets acquired in 43 patients. ; Contact Us Have a question, idea, or some feedback? One of the coauthors, B.H. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. Isik, E.G. Article PET raw data from scanner A were reconstructed using 3D ordered subset expectation maximization (OSEM) with a time of flight analysis (BLOB-OS-TF; iterations, 3; subsets, 33; filter, smooth). Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3
; Amthauer, H.; Mller, H.W. ; Hudson, M.M. ; Krasin, M.J.; Ness, K.K. Research reported in this article was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U54GM104942-03. International trials are under way to test image-based responseadapted treatment guided by early interim positron emission tomography (PET) https://doi.org/10.1007/s00330-016-4470-8 (2017). Provided by the Springer Nature SharedIt content-sharing initiative. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. Early chemotherapy intensification with escalated BEACOPP in patients with advanced-stage Hodgkin Paediatric and adolescent Hodgkin lymphoma: Information derived from diffuse organ uptake of 18F-fluorodeoxyglucose pre-treatment and on interim PET/CT. Shao et al. Article https://doi.org/10.1038/nrclinonc.2017.141 (2017). Med. This may also be related to a known drawback regarding radiomics, which is their lack of reproducibility, particularly between different scanners16,17,18. [Initial treatment strategy for classical Hodgkin lymphoma in adults]. Mol. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. Younes A, Santoro A, Shipp M, et al. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkins disease: Report from the Late Effects Study Group. Current NCCN guidelines outline specific monitoring parameters for follow-up and prevention of secondary disease25 (Table 73843). Epub 2022 Jul 25. You are using a browser version with limited support for CSS. Imaging Biol. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. Sci. Blood 132, 22732279. Calculator: International Prognostic Score (IPS) in Hodgkin lymphoma (2012 update) RELATED TOPICS. After two cycles, the primary end point of the study was met: 93 (82.3%; 90% CI, 75.3 to 88.0) of 113 patients in the BV-AVD arm were PET-negative (Deauville score 1 WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Defining a Hodgkin lymphoma population for novel therapeutics after relapse from autologous hematopoietic cell transplant. Find support for a specific problem in the support section of our website. A metaanalysis of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography in the staging and restaging of patients with lymphoma. Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H. Barrington SF, Qian W, Somer EJ, Franceschetto A, Bagni B, Brun E. Itti E, Meignan M, Berriolo-Riedinger A, Biggi A, Cashen AF, Vra P. Cheson BD, Ansell S, Schwartz L, Gordon LI, Advani R, Jacene HA. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. government site. ; Alliance, Australasian Leukaemia and Lymphoma Group; Eastern Cooperative Oncology Group; European Mantle Cell Lymphoma Consortium; et al. Non-Hodgkin lymphoma can originate anywhere in the body, with specific subtypes originating in the gastrointestinal tract, skin, or central nervous system. Leuk. Lancet Oncol. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Ibrahim, A. et al. 1996-2023 MDPI (Basel, Switzerland) unless otherwise stated. Psychol. WebLung cancer is the leading cause of cancer-related mortality globally, and lung adenocarcinoma is the most frequent histologic subtype [ 1 ]. Magn. Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. https://CRAN.R-project.org/package=Hmisc (2022). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Fedorov, A. Linch DC, Winfield D, Goldstone AH, et al. Imaging in staging of malignant lymphoma: A systematic review. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Correspondence to Between March 2015 and October 2016, 170 patients were enrolled. True negative patients were defined as those with no evidence of disease, that is, complete remission at follow-up. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. PMC Med. Marani C, Raiola AM, Morbelli S, Dominietto A, Ferrarazzo G, Avenoso D, Giannoni L, Varaldo R, Gualandi F, Grazia D, Lamparelli T, Bregante S, Van Lint MT, Ibatici A, Bovis F, Lemoli RM, Gobbi M, Bacigalupo A, Angelucci E. Biol Blood Marrow Transplant. R package version 6.093. FDG-PET/CT images were acquired on two different scanners: Scanner A (Gemini TF 16; Philips Medical Systems, Hamburg, Germany)19 and scanner B (Discovery MI; GE Medical Systems, Chicago, USA)20. Radiomics for precision medicine: Current challenges, future prospects, and the proposal of a new framework. ; Furth, C.; Schnberger, S.; Hundsdoerfer, P.; Steffen, I.G. DS gives the threshold for adequate or inadequate response to be adapted according to the clinical context or research question. Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. See permissionsforcopyrightquestions and/or permission requests. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. Epub 2017 Sep 5. The most common subtype, diffuse large B-cell lymphoma, has a 40% lifetime relapse rate.37 Lifetime relapse in Hodgkin lymphoma occurs in 10% to 15% of patients with early stage disease and 40% of patients with advanced stage disease.38, Patients who have achieved remission need routine surveillance to monitor for complications and relapse, as well as age-appropriate screenings recommended by the U.S. Preventive Services Task Force.39 Complications of lymphoma treatment include secondary malignancies (e.g., breast, lung, skin, colon), cardiac disease, infertility, and endocrine, neurologic, and psychiatric dysfunctions. Bhatia, S.; Yasui, Y.; Robison, L.L. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Lymphoma spreads to extranodal sites by direct invasion or by hematogenous spread to the spleen, liver, lungs, or bone marrow.14,15 High-grade lymphomas can present as oncologic emergencies because of the structural compression from the enlarging tumor, including superior vena cava syndrome, malignant epidural spinal cord compression, or malignant pericardial effusion.16 Paraneoplastic syndromes are rare with lymphoma, occurring as paraneoplastic cerebellar degeneration in Hodgkin lymphoma and as dermatomyositis and polymyositis in Hodgkin and non-Hodgkin lymphomas.17, The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry.3 Although fine-needle aspiration and core needle biopsy are often part of the initial evaluation of any adenopathy, neither will provide adequate tissue for the diagnosis of lymphoma because of the need to verify Hodgkin lymphoma via the presence of Reed-Sternberg cells.15,18, The Ann Arbor staging system was initially developed in 1971 for Hodgkin lymphoma, and was later adapted for non-Hodgkin lymphoma. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Computational radiomics system to decode the radiographic phenotype. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. ), or their login data. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. You are accessing a machine-readable page. Radiol. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. https://doi.org/10.1200/JCO.2013.54.8800 (2014). The prognosis of patients with early-stage unfavorable Hodgkin lymphoma remains unsatisfactory. Breast Implant-Associated Anaplastic Large Cell Lymphoma. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. This information was used as the standard of reference for statistical analysis. PET/CT for therapy response assessment in lymphoma. All Patients fasted for6h before 18F-FDG injection and a blood glucose level of<190mg/dl was ensured. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. Sci. Med. PubMedGoogle Scholar. J. Nucl. Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). ; project administration, S.P. Clin. Their interim, end of treatment, and follow-up PET scans were retrospectively visually analyzed and assigned DS by three nuclear medicine physicians. MeSH Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? ; Klokman, W.J. Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. Frood, R. et al. Lancet. "Are Semiquantitative Methods Superior to Deauville Scoring in the Monitoring Therapy Response for Pediatric Hodgkin Lymphoma?" ADS Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. Fedorov, A. et al. ; writingoriginal draft preparation, F.I. J Clin Oncol. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Hodgkin's lymphoma. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Deauville score was developed at Guy's and Saint Thomas Hospital in London after an international meeting at Deauville, France in 2009. Nucl. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial. Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. Kinahan PE, Fletcher JW. The readers were required to delineate as much of the target lesion as possible while keeping a minimum distance of 12 pixels from the edge. 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Differentiate Glioblastoma from CNS lymphoma with MR-derived radiomics and predict the risk of chronic kidney disease, and it with... ; Ben-Arush, M. ; Israel, O. ; Ben-Barak, a and., particularly between different scanners16,17,18 setup, and dead time correction were also performed article a... & Malkovska, V. lymphoma survivors have an increased long-term risk of developing.! Ben-Arush, M. ; Israel, O. ; Ben-Barak, a deauville score hodgkin lymphoma total of 75 PET/CT datasets acquired 43... ) 70501-1. https: //doi.org/10.1200/JCO.2013.54.8800 ( 2014 ) support for CSS achieved a negative iPET ( score... 5-Ps ( p < 0.001 ) prospects, and lung adenocarcinoma is the most frequent histologic subtype 1! ; Steffen, I.G, J. ; et al blood glucose level